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AGS MEETING: ProMem Improves Symptoms Of Alzheimer’s PHILADELPHIA, PA -- May 25, 1999 -- An analysis of pooled data from a series of trials of Bayer Corp.'s' ProMem(TM) (metrifonate), a long-lasting acetylcholinesterase inhibitor for the treatment of Alzheimer's disease, indicates that ProMem-treated patients experience improvements in cognition, psychiatric and behavioural symptoms and activities of daily living. These findings were released at the American Geriatric Society annual meeting. The results of the study, which was based on an analysis of pooled data from double-blind, placebo-controlled clinical trials with 1,201 patients in the United States, Britain and France was to determine how many patients responded to ProMem treatment in any of the three key clinical domains: cognition, behaviour and activities of daily living. An overwhelming majority of ProMem patients in both dose groups (91 percent for the 60/80mg per day, and 89 percent of the 50mg or equivalent per day) responded in at least one clinical domain when compared to baseline over the course of 26 weeks of treatment. "The beneficial effects of ProMem may translate into clinical benefits across a wide range of symptoms for this population of mild-to-moderate Alzheimer's disease patients," said lead author Martin Farlow, professor of neurology and vice chairman for research, department of neurology, Indiana University School of Medicine in Indianapolis. ProMem is currently under review by the U.S. Food and Drug Administration for the treatment of mild-to-moderate dementia of the Alzheimer's type. ProMem increases levels of the neurotransmitter acetylcholine in the brain by blocking acetylcholinesterase, an enzyme that breaks down acetylcholine. E-mail this page to a friend or colleague! To print, use this version