DG Dispatch - AAN: No Escaping Dementia As We Get Older
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DG Dispatch - AAN: No Escaping Dementia As We Get Older

By Cameron Johnston
Special to DG News

TORONTO, ON -- April 23, 1999 -- No matter how healthy people remain into their old age, it appears that sooner or later, they will develop dementia - perhaps not clinical Alzheimer’s disease, but dementia nonetheless, according to a study presented by University of Oregon researchers at the AAN meeting.

The study looked at 160 patients who ranged in age from 67-107, who were given a complete neurological examination once per year over a five-year period. The patients were also evaluated every six months to determine their level of dementia using such tests as the Mini-Mental State Exam (MMSE) and Clinical Dementia Rating (CDR).

Although all of the subjects were mentally healthy at the start of the study, many became demented over the five-year period.

Dr. Haydeh Payami, a research fellow in neurology in Oregon concluded that the lifetime risk of suffering some mild impairment by the age of 105 is 100 percent, and there is a 45 percent chance that the diagnosis will be clinically-defined as Alzheimer’s.

Of the 14 subjects who died during the study and were given an autopsy, all but one had varying degrees of Alzheimer’s pathology in their brains.

The study also revealed a connection between genetics and gender, showing women who have one allele of the apolipoprotein e-4 to be 11 times more likely to develop Alzheimer’s disease than men with this apolipoprotein.

In a remarkable turn, Dr. Payami said although hormone replacement therapies seem to offer women a protective benefit against dementia, in this study at least, the women who had taken hormone replacements actually showed a faster decline and loss of cognitive function than those who had not taken hormones.

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