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Celebrex Approved in Mexico For Treatment Of Arthritis CHICAGO, IL -- Feb. 11, 1999 -- The Mexican Health Secretariat has approved G.D. Searle & Co.’s and Pfizer Inc.’s Celebrex(TM) (celecoxib) for the treatment of the signs and symptoms of osteoarthritis and rheumatoid arthritis and for the management of pain. Celebrex is an important treatment alternative for millions of people with arthritis. Celebrex was tested in clinical trials that involved over 13,000 patients and healthy volunteers enrolled in more than 50 different clinical studies in 23 countries world-wide. In clinical trials, Celebrex was shown to be as effective as the prescription-strength nonsteroidal anti-inflammatory drug (NSAID) naproxen in treating arthritis pain and inflammation. In OA patients, Celebrex improved pain, stiffness and patient functions, such as walking, bending and getting in and out of a car. Importantly, Celebrex was associated with significantly fewer upper gastrointestinal (GI) ulcers than both naproxen and another widely-used arthritis medication, ibuprofen. Celebrex was designed using advanced molecular technology. Scientists believe that Celebrex works by inhibiting an enzyme called COX-2, which plays a role in pain and inflammation. However, Celebrex, at therapeutic doses, does not inhibit the COX-1 enzyme, which helps maintain the normal stomach lining. NSAIDs in general inhibit both COX enzymes, so they treat pain and inflammation but may damage the stomach lining, potentially leading to ulcers in some patients. Arthritis is a chronic condition characterised by pain and inflammation of the joints (such as the knees, hips, fingers, feet, spine and shoulders). The most common type of arthritis, osteoarthritis, is a degenerative joint disease in which cartilage that covers the ends of the bones in the joint deteriorates, causing pain and loss of movement. Rheumatoid arthritis is an autoimmune disease in which the joint lining becomes inflamed as part of excessive immune system activity. Rheumatoid arthritis often results in destruction of the joint, pain and disfigurement, and limits the normal range of motion of the affected joint. E-mail this page to a friend or colleague! To print, use this version