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Raising HDL Cholesterol Reduces Incidence Of Coronary Events MIAMI, FL -- Nov. 11, 1998 – Results from the High Density Lipoprotein Intervention Trial (HIT) show that raising high density lipoprotein (HDL), the good cholesterol, significantly reduces the incidence of coronary events. The results were presented yesterday at the 71st annual American Heart Association meeting. The results of the trial clearly suggest that raising HDL is at least as important as lowering LDL, the bad cholesterol. HIT included 2,531 patients with documented coronary heart disease (CHD) with depressed levels of HDL but normal levels of LDL and triglycerides. The seven-year study showed that an eight percent increase in HDL resulted in a significant 22 percent reduction in the incidence of CHD-death and non-fatal myocardial infarction. HIT researchers also found a greater than 25 percent reduction in stroke associated with raising HDL cholesterol. "The results of HIT have far-reaching clinical implications, especially for CHD patients," said HIT investigator, Moti Kashyap, M.D., professor of medicine, University of California, Irvine and Director, Cholesterol Center, Long Beach Veterans Affairs Medical Center. "HIT demonstrates that raising HDL is a clinical imperative, along with lowering LDL cholesterol, for managing patients at risk for heart disease." HIT is the first major clinical evidence to suggest the benefits of raising HDL and lowering triglycerides. The results are consistent with conclusions from the Framingham study and other epidemiological studies demonstrating that for each one percent increase in HDL cholesterol, the risk of CHD decreases by two to three percent, whereas a one percent reduction in LDL results in only a one percent decrease in CHD risk. "The dramatic results from HIT suggest that HDL cholesterol may be as important a risk factor as LDL cholesterol and certainly point to the need for the clinical use of therapies that can effectively raise HDL cholesterol," said Peter Kwiterovich, M.D., director of lipid research-atherosclerosis and professor of medicine and pediatrics, Johns Hopkins University Hospital. Of the 14 million Americans who have CHD, about one-third have low levels of HDL cholesterol as their primary lipid abnormality. Common therapies such as statins that target elevations in LDL cholesterol are only effective in reducing coronary events in about 30 percent of the population at risk, leaving 70 percent of dyslipidemic patients at risk for heart disease without effective treatment. E-mail this page to a friend or colleague! To print, use this version