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Remeron More Effective, Faster Working Than Cipramil or Paxil, Study Shows PARIS, FRANCE -- Nov. 3, 1998 -- Study results presented today show that Organon’s Remeron® (mirtazapine) is more effective and has a faster onset of action than the selective serotonin reuptake inhibitors Cipramil® (citalopram) and Paxil® (paroxetine). "These studies are very persuasive and add to growing evidence that dual-acting antidepressants like Remeron, which increase levels of both noradrenaline and serotonin, are genuinely more effective than the selective serotonin reuptake inhibitors," said professor Siegfried Kasper, professor of psychiatry at the University of Vienna, who presented the findings at the European College of Neuropsychopharmacology meeting. "In addition, the results from these studies suggest Remeron’s action is not just stronger, but also quicker." These results follow the recent publication in the Journal of Clinical Psychiatry which shows that Remeron shows superior efficacy to Prozac®(fluoxetine). In the eight-week, head-to-head, double-blind trial of Remeron and Cipramil involving over 260 patients, those taking Remeron showed a significantly greater improvement in symptoms of depression at week two compared to Cipramil. The dose ranges were 15 to 60 mg for Remeron and 20 to 60 mg for Cipramil, in line with usual clinical practice. In the trial against Paxil, based on a similar design, patients taking Remeron had a statistically-significant greater improvement in symptoms of depression at week one than those taking paroxetine. Moreover, the number of patients responding to Remeron was greater at all timepoints, reaching statistical significance at both week one and week four. In both comparative studies, patients taking Remeron experienced less SSRI-associated side effects such as headache, nausea and sweating and there was no statistical difference in the number of patients experiencing somnolence. Related Links: Remeron, Paxil and Organon E-mail this page to a friend or colleague! To print, use this version