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Majority Of Women Reach LDL Targets With Lipitor, Study Shows TORONTO, ON -- Oct. 26, 1998 -- The results of the Women’s Atorvastatin Trial on Cholesterol (WATCH), an all-women Canadian cardiovascular research study, show that Parke-Davis’ Lipitor® (atorvastatin calcium) is effective in assisting women to reach targets for LDL cholesterol (LDL-C). The study results were announced at the recent Canadian Cardiovascular Society annual meeting in Ottawa. The 16-week study, conducted at 43 centres in Canada with 318 women aged 18 to 75, determined that when patients were put on Lipitor (10 mg to 80 mg), 87 percent of women with two or more risk factors for coronary heart disease (CHD) reached target LDL-C levels, while 81 percent of women with established CHD reached target LDL-C levels. "The WATCH results will provide physicians with the valuable information needed to adequately treat women with coronary and other atherosclerotic diseases, or heart disease risk factors to appropriate LDL target levels," said Dr. Jacques Genest Jr., principal co-investigator of the study. "Not only did the majority of women reach established U.S. LDL target levels, but they also met the more aggressive new recommended Canadian cholesterol treatment guidelines recently developed." The WATCH study involved the cholesterol-lowering drug, Lipitor, an HMG-CoA reductase inhibitor, or statin. Women with CHD and/or U.S. NCEP (National Cholesterol Education Program) risk factors for CHD and other atherosclerotic diseases (for example, age, smoking, diabetes, family history of heart disease, hypertension, low HDL cholesterol levels or menopausal status) were enrolled. The study focused on the ability of Lipitor to achieve U.S. NCEP LDL-C treatment goals according to the presence of CHD risk factors or established CHD. It is estimated that 4.2 million Canadian adults have LDL-C levels that warrant dietary intervention and fewer than one-third of those who should be treated with drug therapy for high cholesterol are receiving such therapy. The incidence of heart disease increases sharply in postmenopausal women. This is primarily due to the decline of women’s estrogen levels as menopause is reached, resulting in higher LDL-C levels and lower HDL-C levels. Related Links: Lipitor E-mail this page to a friend or colleague! To print, use this version