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CombiPatch Now Available In U.S. For Menopause Symptoms COLLEGEVILLE, PA -- Sept. 30, 1998 -- Rhone-Poulenc Rorer’s CombiPatch™ (estradiol/norethindrone acetate), the first hormone replacement therapy (HRT) to combine both estrogen and progestin in a single transdermal patch is now available for menopausal women with an intact uterus for the relief of moderate-to-severe vasomotor symptoms such as hot flashes, night sweats and vaginal dryness. CombiPatch is the first transdermal product in the U.S. to administer a continuous dose of both estrogen and progestin. Previously, women who would benefit from both estrogen and progestin had only two options: either oral estrogen and progestin or an estrogen transdermal patch used with an oral progestin. CombiPatch delivers the estrogen 17-beta-estradiol and the progestin norethindrone acetate (NETA) through a state-of-the-art matrix patch technology that releases the two hormones from the patch's adhesive. The matrix technology allows CombiPatch to be clear, thin and discreet in appearance and it requires changing only twice a week. Menopause, the life stage that typically occurs in women between the ages of 45 and 55, is marked by a gradual reduction in the production of the hormone estrogen. This decrease leads to a host of symptoms, including hot flashes, night sweats and vaginal dryness. The American College of Obstetricians and Gynecologists reports that more than one-third of all women in the U.S. are older than 50, and another 20 million women of the baby boomer generation are due to reach menopause within the next decade. In a three-month vasomotor clinical trial of CombiPatch, the most common side effects were breast pain and dysmenorrhea. Estrogens should not be used in women with known or suspected pregnancy, breast cancer, or estrogen-dependent neoplasia, undiagnosed abnormal genital bleeding, active thrombophlebitis, or thromboembolic disorders. Estrogens given without progestins have been reported to increase the risk of endometrial carcinoma in postmenopausal women. Progestins taken with estrogen drugs significantly reduce, but do not eliminate, the risk of endometrial cancer that is associated with the use of estrogen. E-mail this page to a friend or colleague! To print, use this version