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ACG: Fewer Than Expected Ulcer Patients Infected With H. Pylori PHOENIX, AZ -- October 18, 1999 -- A prospective study in duodenal ulcer patients found that infection with the Helicobacter pylori (H. Pylori) bacterium - once implicated in over 90 percent of ulcers - was present in only 55 percent of patients. The research was conducted at Johns Hopkins Medical Center and reported by Dr. John Lee at the Annual Scientific Meeting of the American College of Gastroenterology (ACG). The researchers enrolled patients with ulcers at the Hopkins Endoscopy Unit and took biopsies as well as blood tests for the presence of H. pylori. Of the 20 patients for whom complete data are available in this ongoing research, 75 percent were men and the median age was 63 years. Only 55 percent of patients with duodenal ulcers were positive for H. pylori. In both patients with and without H. pylori infection, there was no difference in the use of non-steroidal anti-inflammatory drugs (NSAIDs)-another cause of some ulcers-or acid suppressant drugs known as proton pump inhibitors (PPIs). Of the H. pylori infected patients, 55 percent used NSAIDs; among the H. pylori negative patients, 54 percent used NSAIDs. PPI use was 18 percent among H. pylori positive individuals compared to 22 percent among those who were not infected with H. pylori. These findings support recent retrospective studies that suggested a decrease in the incidence in H. pylori infection associated with duodenal ulcers. E-mail this page to a friend or colleague! To print, use this version