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COX-2 Inhibitor, Celebra, Approved In Brazil For Arthritis Treatment CHICAGO, IL -- Jan. 21, 1999 -- The Brazilian Ministry of Health has approved GD Searle & Co.’s and Pfizer Inc.’s Celebra(TM) (celecoxib) for the treatment of arthritis. Celebra, the first in a group of anti-inflammatory and analgesic medications which act through the mechanism of specific COX-2 inhibition, is marketed as Celebrex in the United States. In clinical trials, Celebrex was shown to be as effective as the prescription-strength nonsteroidal anti-inflammatory drug (NSAID) naproxen in treating arthritis pain and inflammation. Celebrex was designed using advanced molecular technology. Scientists believe that Celebrex works by inhibiting an enzyme called COX-2, which plays a role in pain and inflammation. However, Celebrex, at therapeutic doses, does not inhibit the COX-1 enzyme, which helps maintain the normal stomach lining. NSAIDs in general inhibit both COX enzymes, so they treat pain and inflammation but may damage the stomach lining, potentially leading to ulcers in some patients. Arthritis is a chronic condition characterised by pain and inflammation of the joints (such as the knees, hips, fingers, feet, spine and shoulders). The most common type of arthritis, osteoarthritis, is a degenerative joint disease in which cartilage that covers the ends of the bones in the joint deteriorates, causing pain and loss of movement. E-mail this page to a friend or colleague! To print, use this version