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Astelin As Effective As Combination Therapy For Allergy Symptoms CRANBURY, NJ -- Jan. 8, 1999 -- Results from new comparative clinical trials, presented at the annual meeting of the American College of Allergy, Asthma and Immunology showed that Wallace Laboratories’ Astelin(R) Nasal Spray monotherapy was as effective as oral antihistamine (loratadine) plus intranasal corticosteroid (beclomethasone) combination therapy. The comparative study was a multicentre, double-blind, randomised, parallel-group trial of 362 patients conducted during the spring 1998 allergy season. Enrolled patients had moderate-to-severe nasal and non-nasal symptoms that had been inadequately controlled by oral antihistamine monotherapy or by intranasal steroid therapy. Patients were randomised to receive treatment for seven days with either Astelin Nasal Spray monotherapy or combination therapy of an oral antihistamine (loratadine) plus an intranasal corticosteroid (belcomethasone). In this study, there was no statistically significant difference between the Astelin Nasal Spray monotherapy group and the combination therapy group in controlling nasal and non-nasal seasonal allergic rhinitis symptoms. The most frequently observed adverse events were headache, somnolence and rhinitis. Related Links: Astelin, Wallace Laboratories E-mail this page to a friend or colleague! To print, use this version