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Selegiline Approved for Parkinson's Disease WILMINGTON, Del., Aug. 5, 1996 -- The DuPont Merck Pharmaceutical Company (DuPont Pharma) announced today that Carbex(TM) (selegiline HCl) Tablets, USP, have been cleared for marketing by the Food and Drug Administration as adjunctive therapy for managing Parkinson's disease symptoms. CARBEX, which is available in tablet rather than capsule form is bioequivalent, and therefore, therapeutically equivalent to Eldepryl(R) (selegiline hydrochloride) tablets as indicated in the treatment of Parkinson's disease. CARBEX will complement DuPont Pharma's established line of Parkinson's disease therapies, including Sinemet(R) CR (Carbidopa-Levodopa) Sustained-Release Tablets, immediate-release Sinemet(R) (Carbidopa-Levodopa) Tablets and Symmetrel(R) (amantadine hydrochloride) capsules. Sinemet(R) CR and Sinemet(R) are the standard prescriptions for Parkinson's disease in the U.S. More than one million Americans suffer from Parkinson's disease, a progressive neurological disorder that affects muscle control. The disease is believed to be caused by a lack of dopamine in the brain. CARBEX is used as an adjunctive therapy with Sinemet(R) CR and Sinemet(R) when there is a deterioration in the quality of response to levodopa/carbidopa therapy. CARBEX prevents the enzyme monoamine oxidase type B (MAO B) from breaking down dopamine in the brain. This allows dopamine to remain active in the brain for a longer period of time. Common side effects of selegiline include nausea, dizziness, confusion, hallucinations and dykskinesia (uncontrolled movements). CARBEX is contraindicated in patients with hypersensitivity to selegiline hydrochloride and in patients taking Demerol(R) (meperidine HCl, USP). DuPont Merck Pharmaceutical Company is a worldwide, research-based pharmaceutical company. Formed in 1991 as a partnership between DuPont (NYSE: DD) and Merck & Co., Inc. (NYSE: MRK), DuPont Merck is focused on research, development and delivery of pharmaceuticals to treat unmet medical needs and the fight against heart disease, central nervous system disorders, cancer, HIV and arthritis-related disorders. The company is also a leader in radiopharmaceuticals. DuPont Merck markets its products under the DuPont Pharma name. E-mail this page to a friend or colleague! To print, use this version