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Testosterone Improves Quality Of Life In Men With AIDS Wasting Syndrome BOSTON, MA -- July 2, 1998 -- A research team based at the Massachusetts General Hospital (MGH) has found that testosterone administration significantly increases lean body mass and improves the quality of life in men with AIDS wasting syndrome. The AIDS wasting syndrome is a devastating complication of late-stage HIV infection, characterised by an extreme loss of lean muscle mass, leading to significant fatigue and frailty. The report appears in yesterday’s issue of Annals of Internal Medicine. "This is an important new therapy for patients with AIDS wasting syndrome," said Steven Grinspoon, MD, of the MGH Neuroendocrine Unit, who led the study. "Physicians now will have a important tool to help build critically needed muscle mass and improve overall well being in men with AIDS wasting syndrome." Fifty-one HIV-positive men aged 34 to 50 participated in the study. They were selected because they had significant weight loss and low testosterone levels. Participants were randomly assigned to receive injections of either testosterone or a placebo every three weeks for six months. Injections were designed to produce normal testosterone levels in those receiving the hormone. Compared with the placebo group, those who received testosterone had significant term benefit," he explained. "We believe all male patients with AIDS wasting syndrome should be screened for hormone deficiency and given testosterone if their levels are low, unless there is a medical reason not to do so." E-mail this page to a friend or colleague! To print, use this version