Indications Expanded for Antifungal AmBisome In Spain
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Indications Expanded for Antifungal AmBisome In Spain

BOULDER, CO -- June 11, 1998 -- The Spanish Ministry of Health has approved expanded indications for NeXstar Pharmaceuticals Inc.’s AmBisome, a liposomal formulation of amphotericin B.

The new, broader label now includes first-line treatment in severe confirmed systemic fungal infections; empirical treatment for fungal infections in severely neutropenic patients; and treatment for visceral leishmaniasis in immune-compromised patients who have failed amphotericin B or other conventional therapy.

The new label in Spain recommends that AmBisome therapy should be administered at doses of 1 to 3 mg/kg/day. In specific cases of extremely severe fungal infections, doses up to 5 mg/kg/day may be used.

AmBisome now has first line indications in 16 countries world-wide.

Patients at risk for systemic (blood-borne) fungal infections include those with compromised immune systems, such as patients receiving cancer treatment, HIV-infected individuals and bone marrow transplant patients. Patients afflicted with systemic fungal infections have low levels of infection-fighting white blood cells and exhibit persistent fever that does not resolve despite large-spectrum antibiotic treatment. These fungal infections are often lethal in the absence of effective therapy.

More information on: AmBisome, NeXstar Pharmaceuticals Inc.

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