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AAN MEETING: Study Shows Migraine And Depression May Be Treated Together MINNEAPOLIS, MN -- April 30, 1998 -- Migraine and depression, two commonly linked conditions, may now be treated together, according to results of a new study presented today at the 50th annual meeting of the American Academy of Neurology. The study showed that Zeneca Pharmaceuticals’ oral medication for the treatment of acute migraine Zomig(TM) (zolmitriptan), is safe when taken with the antidepression treatment fluoxetine, commonly known by its trade name Prozac. Other migraine therapies, including sumatriptan, have been shown to interact with fluoxetine. An estimated 25 to 30 million people suffer from migraine in the United States. Studies of migraine and depression show consistent evidence of a substantial association between these two conditions because of their common link -- serotonin. With the onset of a migraine attack, serotonin activity in the brain changes dramatically. Changes in serotonin activity within the brain also are thought to be involved in depression. "Given that depression and migraine often occur together, it is likely that some patients may take Zomig and an antidepressant at the same time," said Gerardo Torres, M.D., US Project Physician for Zomig. "Our research suggests migraine patients who suffer from depression may treat both diseases safely with this combination of drugs." The objective of the study was to investigate the effect of multiple doses of fluoxetine on the blood levels and safety profile of Zomig. In this randomised, double-blind, two-period crossover study, 20 healthy male and female volunteers received fluoxetine or placebo daily for 28 days. With the last dose of fluoxetine or placebo, subjects took a single oral dose of Zomig in the fasting state. Results of the study show fluoxetine has no effects on the blood levels of Zomig or its metabolites. Zomig was well tolerated when given alone or with fluoxetine. There was a small clinically insignificant increase in blood pressure following Zomig, which was unaltered by fluoxetine. E-mail this page to a friend or colleague! To print, use this version