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| |  AAN MEETING: Levodopa May Improve Attention Deficit Symptoms MINNEAPOLIS, MN -- April 30, 1998 -- By treating children's sleep disorders, parents may find that their children’s attention deficit hyperactivity disorder (ADHD) improves as well, according to a study released during the American Academy of Neurology's 50th anniversary annual meeting, this week in Minneapolis, MN. The study involved children with ADHD as well as restless legs syndrome and/or periodic limb movements of sleep. ADHD is a chronic, neurologically based syndrome characterised by restlessness, distractibility and impulsivity. Restless legs syndrome is a neurological disorder characterised by sensations of discomfort in the legs during periods of inactivity relieved by moving or stimulating the legs. Periodic limb movements of sleep involves episodes of repetitive leg movements causing brief awakenings in brain activity. Both sleep disorders can cause interrupted sleep and fatigue or sleepiness during the day. In the study, five children were treated with the drug levodopa, which has been shown to improve symptoms of these sleep disorders but not ADHD. "The children showed marked improvement," said neurologist Arthur Walters, MD, of the UMDNJ-Robert Wood Johnson Medical School and Lyons VA Medical Center in New Brunswick, NJ. "Their sleep disorders improved, and so did their behaviour and mental acuity." The children's attention spans improved, along with their memory and parents reported that their children's behaviour improved. Walters said the sleep disruption may cause the children to be inattentive and hyperactive due to sleep deprivation. The children also may have leg discomfort when sitting at their school desks that is relieved only by moving around, he said. "It is not definitely proven that periodic limb movements of sleep leads to symptoms of ADHD. An alternative possibility is that these disorders simply appear together frequently," Walters added. Children with ADHD have a higher incidence of periodic limb movements of sleep than children who don't have ADHD, Walters said. Also, the parents of children with ADHD and periodic limb movements of sleep have a higher incidence of restless legs syndrome than other parents. Researchers also have another theory why levodopa improves the children's ADHD symptoms. "There may be a common link -- a dopaminergic deficiency in the brain that causes both the sleep disorders and the ADHD," Walters said. One argument supporting this theory is that Ritalin(R), a common treatment for ADHD, promotes dopamine action in the brain, as does levodopa. "No one understands why a stimulant -- Ritalin -- improves hyperactive behaviour," Walters said. "This could be why." Walters said the benefits of the levodopa appear to last long term. The next step to confirm these results is a double-blind, placebo-control trial, he said. The drug should also be tested with children with ADHD who do not have these sleep disturbances, he said.
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