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Study Links Popular Cardiovascular Drugs To Suicide LONDON, ENGLAND -- March 6, 1998 -- In a study including 152 Swedish municipalities (total population of 7.3 million), Dr. Anne Melander, professor of pharmacoepidemiology, Swedish Network for Pharmacoepidemiology Foundation, Malm University Hospital in Sweden, and colleagues investigated possible associations between the use of cardiovascular drugs and suicide and the results of this study are published in this week's British Medical Journal. The authors found a significant correlation between the use of calcium channel blockers and the incidence of suicide (that remained significant when differences in cardiovascular morbidity were considered). Furthermore, in a five year study of drugs for high blood pressure, the authors found a five-fold increase in the incidence of suicide in users of calcium channel blockers compared with users of other antihypertensives. Among the Swedish municipalities the use of each cardiovascular drug group except angiotensin converting enzyme inhibitors correlated significantly and positively with suicide rates. After adjustment for the use of other cardiovascular drug groups, as a substitute for the prevalence of cardiovascular morbidity, only the correlation with calcium channel blockers remained significant. In the cohort study, five users and four non-users of calcium channel blockers committed suicide during the follow up until the end of 1994. The absolute risk associated with use of calcium channel blockers was 1.1 suicides per 1,000 person years. The relative risk, adjusted for differences in age and sex, among users versus non-users was 5.4. The researchers conclude that calcium channel blockers should be considered a possible cause of depression and suicide. E-mail this page to a friend or colleague! To print, use this version