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Major Breakthrough in Diabetes Research NEW YORK, Aug. 11, 1995 -- Representing a major breakthrough in diabetes research, investigators at the Brigham and Women's and the Massachusetts General Hospital in Boston have identified two genes that may contribute to the disease and functionally demonstrate the ability of normal copies of these genes to correct diabetic cells in the majority of patients. This work is published Aug. 11 in the peer-reviewed journal, HUMAN GENE THERAPY. The greater than 20-year search to identify as well as genetically correct a cellular defect of human diabetes is a joint collaboration between two Harvard investigators, virologist Dr. Fred Wang and immunologist Dr. Denise Faustman, working on Type I diabetes. "This work shows that it is possible to use a patient's own cells and correct them and reinfuse them," Dr. Faustman said. "This has tremendous implications for patients who have recurrent disease after pancreas transplantation and for patients who are at great risk for diabetes. "Human treatments are years off, however. The pace of research applications is directly related to available funding," explained Dr. Faustman. "If the funding were available, we could scale up and go into clinical trials, but diabetes research is less well funded than breast cancer research, for example, even though there are 14 million Americans with diabetes." In Type I diabetes, patients require insulin for life and die at early ages from the complications of poorly controlled blood sugars. E-mail this page to a friend or colleague! To print, use this version