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Study Supports Statin Use in Elderly Patients Undergoing PCI: Presented at SCAI By Thomas S. May ORLANDO, FL -- May 11, 2007 -- Patients over 75 years of age who undergo percutaneous coronary intervention (PCI) derive long-term benefits from statin therapy similar to those observed in younger patients, according to research presented here at the 30th Annual Scientific Sessions of the Society for Cardiovascular Angiography and Interventions (SCAI). The study, presented by Carla Auguadro, resident, department of cardiology, Policlinico di Monza, Monza, Italy, investigated the long-term effects of statins in elderly patients with coronary artery disease (CAD) who underwent PCI and were stable at the time of the intervention. The researchers enrolled 198 consecutive patients 75 years or older who underwent PCI for the treatment of angiographically documented single- or multivessel disease. Most patients had stable CAD; unstable angina was present in 22% of patients. Ninety percent of patients underwent single-vessel percutaneous coronary angioplasty. Tirofiban was administered before starting PCI when indicated (82%) and low-molecular-weight heparin was added to tirofiban in 30% of patients. After PCI, all patients received aspirin (100 mg/day), in addition to ticlopidine (500 mg/day) or clopidogrel (75 mg). No patient died or had major complications during the procedure; however, one patient died before being discharged. At hospital discharge, 69% of patients were receiving statin therapy. After an average of 1.7 years of follow-up, the researchers found that there was a significant reduction in the incidence of major cardiac events among patients who were on statins compared with those who did not receive statin therapy (3% vs. 13%, P =.004). There was no significant difference in the incidence of noncardiac mortality and new revascularisation procedures between patients with and without statin therapy. These results indicate that the administration of statins in elderly patients is as safe and effective as it is in younger patients, according to Dr. Auguadro. "Thus, the implications of our study for clinicians are that the use of statins should be recommended in all patients undergoing PCI, regardless of the patient's age," she said. "Obviously, as in all patients taking statins, liver function should be carefully monitored in elderly patients who are receiving statin treatment," she added. [Presentation title: Percutaneous Coronary Angioplasty in Old Patients: In-Hospital and Long-Term Outcome and Relation with Statin Therapy. Abstract C-53] E-mail this page to a friend or colleague! To print, use this version