HPV Vaccination in Australian Women Significantly Reduced Genital Warts in Women, Men
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HPV Vaccination in Australian Women Significantly Reduced Genital Warts in Women, Men

NEW YORK -- November 9, 2010 -- In 2007, Australia was the first county to fund a human papillomavirus (HPV) vaccination programme for all females aged 12 to 26 years. Three years on, a study published Online First in The Lancet Infectious Diseases has shown that diagnosis of genital warts (caused by HPV infection) have decreased 59%, while heterosexual men (who are not vaccinated) appear to have benefited from herd immunity with a decrease in genital warts diagnoses of 28%.

Basil Donovan, MD, Head of Sexual Health Program, National Centre in HIV Epidemiology and Clinical Research, the University of New South Wales, Sydney, Australia, and colleagues established a national surveillance network in Australia and aimed to identify trends in incidence of genital warts in (2004-09).

In 112, 083 new patients attending sexual health services, 9,867 (9%) had genital warts diagnosed. Before the vaccine programme started in 2007, there was no change in proportion of women or heterosexual men diagnosed with genital warts.

After vaccination began, a decline in number of diagnoses of genital warts was noted for young female Australian residents (59%). No significant decline was noted in female non-residents, women aged older than 26 years in July 2007, or in men who have sex with men.

However, proportionally fewer heterosexual men were diagnosed with genital warts during the vaccine period (28%), and this effect was more pronounced in young men aged 26 years or younger. By 2009, 65.1% of female Australian residents who were eligible for free vaccine reported receipt of the HPV vaccine.

While it will probably be as effective as the quadrivalent HPV vaccine at preventing anogenital and other cancers, the bivalent HPV vaccine used in the UK national program provides no protection against genital warts,” said Dr. Donovan.

The authors also discussed men who have sex with men (MSM), who are not benefiting from the HPV vaccine programme because they do not have access to subsidised vaccine and they are exposed to other unvaccinated men.

“The high morbidity in MSM attributable to HPV-related disease, including anal cancer, and the possible role of anal warts in facilitation of transmission of HIV, means that this group should be considered in future HPV-vaccination programmes,” the authors wrote. “The decrease in frequency of genital warts in young Australian women resulting from the high coverage of HPV vaccination might provide protective effects in heterosexual men through herd immunity.”

SOURCE: The Lancet Infectious Diseases

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