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Wound Infiltration at the End of Total Thyroidectomy Reduces Postoperative Stress, Pain: Presented at ITC By Karen Dente PARIS -- September 19, 2010 -- Local anesthetic wound infiltration, performed at the end of total thyroidectomy, appears to reduce postoperative stress, pain, and analgesia requirements, compared with preincisional infiltration, researchers said here on September 15, 2010 at the 14th International Thyroid Congress (ITC). Ioannis Tsamis, MD, Department of Endocrine Surgery, Hippokration Hospital, University of Athens, Athens, Greece, and colleagues conducted a prospective, double-blinded study of 150 patients undergoing total thyroidectomy by a single surgeon during 2009. Patients were randomised to receive wound infiltration with 10 cc levobupivacaine 0.5% at the end of the operation (group A); pre-incisional infiltration (group B); or no infiltration throughout the surgery (group C). Patients who received wound infiltration at the end of the operation showed significantly less postoperative stress at 12 and 24 hours postoperatively, compared with patients in the other 2 groups. The postoperative pain visual analogue scale scores were also lower in patients who received wound infiltration at the end of surgery, at rest and during movement, compared with the other groups. Analgaesic requirements were also less compared with the other groups. There were no significant differences between groups in preoperative levels of calcium, TSH, T3, T4, Free T3 and T4, and preoperative as well as postoperative serum PTH levels. There were no differences in operative anaesthesia time, histopathology diagnosis, or the weight and volume of the removed thyroid gland. There were no adverse reactions or side effects potentially related to levobupivacaine noticed. [Presentation title: Prospective Randomized Double-Blinded Controlled Study of Local Anesthetic Wound Infiltration in Total Thyroidectomy. Abstract 0910] E-mail this page to a friend or colleague! To print, use this version