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Most Women With Recurrent Miscarriage Have a Good Chance of Having a Live Birth: Presented at ESHRE By John Schieszer STOCKHOLM, Sweden -- July 6, 2011 -- In women with unexplained recurrent miscarriage (RM), approximately 50% may have a subsequent pregnancy that results in a live birth after trying to conceive for 41 weeks, according to data presented here July 4 at the 27th Annual Meeting of European Society of Human Reproduction and Embryology (ESHRE). The study, which was conducted in the Netherlands, found that 14% of women with RM did not become pregnant in 24 months. “Our results mean that women with RM can be reassured that their time to a subsequent conception is not significantly longer than that for fertile women without a history of miscarriage,” said Stef Kaandorp, MD, Center for Reproductive Medicine, Academic Medical Center, Amsterdam, Netherlands. “RM is extremely stressful for these women, and we hope that our study will give them hope and encourage them to keep trying for the baby they want so much.” Dr. Kaandorp and colleagues analysed a subset of subjects in the ALIFE study, which investigated the effect of aspirin alone or combined with low-molecular-weight heparin, compared with placebo, on the live birth rate in women with unexplained RM. The researchers looked at the length of time between randomisation to the moment of the first day of last menstruation before the subsequent pregnancy. For the current study, 251 women were included, and the mean age at the time of diagnosing unexplained RM was 34 years. The women had all had at least 2 miscarriages with an upper gestational age of 20 weeks. The investigators found that 213 women became pregnant during the period of February 2004 to July 2009. A total of 139 had a live birth, 69 a miscarriage, 2 had an ectopic pregnancy, 2 a termination of pregnancy, and 1 had an intra-uterine fetal death. The median time to a subsequent pregnancy, irrespective of outcome, was 21 weeks. The cumulative incidence of natural conception was 56% after 6 months, 74% after 12 months, and 86% after 24 months of which 65% resulted in a live birth. “These women were all randomised to receive 1 of the treatments or placebo, but further analysis showed that these made no difference to the outcome,” said Dr. Kaandorp. “Even such factors as maternal age, body mass index, the number of previous miscarriages, and the presence or absence of a previous live birth did not alter results significantly. Only the presence of Factor V Leiden significantly predicted a shorter time to conception.” Factor V Leiden is a specific gene mutation that results in thrombophilia. He said he hopes that these data will encourage health professionals to avoid non evidenced-based and potentially harmful treatments for couples. For example, aspirin and low-molecular-weight heparin are still being used, even though the ALIFE study showed there is no evidence that they are helpful. [Presentation title: Time to Pregnancy Resulting in a Live Birth in Women With Unexplained Recurrent Miscarriage. Abstract O-022] E-mail this page to a friend or colleague! To print, use this version