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Bevacizumab Receives Broader Label for Metastatic Breast Cancer in Europe NEW YORK -- June 30, 2011 -- The European Commission has extended the existing bevacizumab (Avastin) label to include its use in combination with capecitabine (Xeloda) in metastatic breast cancer. The European Commission had recently confirmed the approval of bevacizumab in combination with paclitaxel chemotherapy for women with metastatic breast cancer in the first-line setting. This new extension provides an additional first-line treatment option for women in whom treatment with other chemotherapies (including taxanes or anthracyclines) is not considered appropriate. The label extension was based on data from the phase 3 RIBBON 1 study which showed a significant increase in progression-free survival when bevacizumab was combined with capecitabine, compared with women who received capecitabine alone (P =.0002). A median PFS of 8.6 months was observed in women receiving bevacizumab plus capecitabine, compared with 5.7 months for women receiving capecitabine alone. Of the women receiving combination therapy, 35.4% experienced a major shrinkage of their tumour compared with 23.6% of those receiving capecitabine alone (P =.0097). SOURCE: Roche E-mail this page to a friend or colleague! To print, use this version