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Most Patients With Chronic HBV, Low Vitamin D Levels Have Detectable Viral Loads: Presented at DDW By Ric Susman CHICAGO -- May 12, 2011 -- About 75% of patients with chronic hepatitis B virus (HBV) infection were found to have insufficient levels of vitamin D, according to a study presented here at Digestive Disease Week (DDW) 2011. “In this outpatient population with chronic hepatitis B, vitamin D insufficiency is prevalent,” reported Katherine Small, MD, Mount Sinai Medical Center, New York, New York, on May 8. “Vitamin D supplementation should be studied prospectively as a therapeutic intervention to increase the likelihood of achieving and undetectable viral load.” In their retrospective database review of 417 patients with HBV, the researchers identified 51 patients who were positive for HBV surface antigen for >6 months. Of these, serum 25-hydroxyvitamin D was measured in 29. Any patients who were being treated for hepatitis C or HIV were excluded from the potential sample pool. Vitamin D levels were analysed according to HBV viral load by the Mann-Whitney-Wilcoxon test. Twenty-two of the 29 patients had vitamin D levels that were considered insufficient. Of these, 3 had very low vitamin D levels (<10 ng/ml). In the patients with undetectable viral loads (4 of 5 patients vitamin D supplementation), vitamin D levels were significantly higher than those of patients who had detectable HBV viral loads (29.1 vs 17.0 ng/ml; P =.003). Digestive Disease Week 2011 is cosponsored by the American Association for the Study of Liver Diseases (AASLD), the American Gastroenterological Association (AGA), the American Society for Gastrointestinal Endoscopy (ASGE), and the Society for Surgery of the Alimentary Tract (SSAT). [Presentation title: Increased Vitamin D Levels are Associated With Undetectable Viral Loads in Patients With Chronic Hepatitis B. Abstract Su1011] E-mail this page to a friend or colleague! To print, use this version