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Condom Use After Cervical Intraepithelial Neoplasia Treatment Reduces Risk of HPV Recurrence: Presented at IPC By Louise Gagnon MONTREAL -- July 13, 2010 -- The use of condoms after treatment of cervical intraepithelial neoplasia (CIN) reduces the risk of recurrence of human papillomavirus (HPV) in women, according to an interim analysis of a 24-month study presented here at the 26th International Papillomavirus Conference (IPC). Investigators conducted an analysis of all women who tested positive for HPV preoperatively. A total of 113 women were recruited to the study, with 1 group receiving routine information of postoperative follow-up while the other group were told to use condoms after CIN treatment, explained Maria Kyrgiou, MD, Watford General Hospital, London, United Kingdom. "There has been a lot of research on condom use for the reduction of HPV infection and the reduction of CIN2 or 3 invasive cervical cancer," Dr. Kyrgiou told Doctor's Guide during an interview on July 7. "We wanted to see if in the population of women who received treatment for CIN, if condom use reduced HPV positivity," she said. "It's a clear message even in a small population in terms of reduction of HPV positivity. It appears using a condom appears to increase significantly HPV clearance." A total of 54 women completed 6 months of follow-up. Investigators observed that positivity for all the tested markers at follow-up was significantly decreased amongst women who were instructed to use condoms after CIN treatment. A total of 22% of those women tested positive for HPV while 57% of their counterparts who did not use condoms tested positive for HPV. Researchers found the number needed to treat was 3. The final study outcome will look at treatment failure at 2 years. "We want to see if they will have recurrence of CIN at 24 months," said Dr. Kyrgiou. The recommendation to use condoms extends to women who are in a monogamous relationship. "They can still get re-infected with the same type of HPV that their partner carries, even if they have only have 1 partner," she added. Longer-term analysis will assess if there is a reduction in treatment failure as possible regression of disease, she added. The next step beyond this study would examine the potential for vaccinating women if they remain free of HPV with condom use, so they do not have to adhere to lifelong condom use, said Dr. Kyrgiou. [Presentation title: Effect of Condom Use After CIN Treatment on HPV Positivity and Other Biomarkers: A Randomised Controlled Trial. Abstract 416] E-mail this page to a friend or colleague! To print, use this version