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Patients With HIV May Suffer Damage to Inner Retinal Leading to Loss of Visual Sensitivity: Presented at WOC By Karen Dente BERLIN -- June 12, 2010 -- A study presented here on June 8 at the World Ophthalmology Congress (WOC) 2010 evaluating the relationship between retinal nerve fibre layer thickness and visual field function in patients with HIV has found that damage to the inner retina early in the disease leads to structural abnormalities and consequently visual field dysfunction. Patients with HIV can display a loss of vision even in the absence of infectious retinitis. Recent studies have shown thinning of the retinal nerve fibre layer (RNFL) in eyes of HIV-positive patients who did not have retinitis using laser scanning ophthalmoscopy, scanning laser polarimetry, and optical coherence tomography (OCT). There is limited information, however, on the association between these anatomic changes and visual sensitivity. Tiago Arantes, MD, Department of Ophthalmology, University of São Paulo, São Paulo, Brazil, and colleagues enrolled 51 eyes of 51 HIV-positive patients and 22 eyes of 22 control patients with clinically normal ocular exam and no previous history of infections retinopathy. All patients were evaluated using the Fast RNFL scan strategy on Stratus OCT and the 24-2 full threshold program on the Humphrey Matrix Frequency Doubling Technology (FDT) perimeter. Associations between RNFL thickness and VF sensitivity were evaluated globally, in 12 clock-hour OCT sectors and in 21 VF zones; linear and quadratic regression models were used in the statistical analysis. Associations were found when regional RNFL thinning was compared with locally measured FDT Matrix pattern deviation (PD), especially between the nasal RNFL measurements and the temporal VF zones (r2 range, 0.108-0.363) and between the superior RNFL measurements and inferior VF zones (r2 range, 0.089-0.318). RNFL thinning and regional loss of VF sensitivity are related in location and severity in HIV-infected patients. "Our study findings support the hypothesis that damage to the inner retina since early stages of the disease lead to structural abnormalities and consequently visual field dysfunction," concluded Dr. Arantes. [Presentation title: Relationship Between Retinal Nerve Fiber Layer Thickness and Visual Field Function in HIV-Infected Patients Without Retinitis. Poster 206] E-mail this page to a friend or colleague! To print, use this version