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Multi-Allergen Microarray Simplifies IgE-Related Allergy Detection: Presented at EAACI By Sara Freeman LONDON -- June 11, 2010 -- A 75-allergen microarray can simplify the detection of immunoglobulin E (IgE).-related allergy in routine practice and can be used for epidemiological research, researchers said here at the 29th Congress of the European Academy of Allergy and Clinical Immunology (EAACI). "IgE testing using allergenic molecules on a microarray system can be done during the routine allergy diagnostic work up," said Adriano Mari, MD, Centre for Clinical and Experimental Allergology, IDI-IRCCS, Rome, Italy, on June 7. The method can generate a wealth of data, Dr. Mari added, which are not only useful for diagnosis of individual patients, but can also be used to better understand the sensitisation process. Sera from 23,077 unselected individuals in the Italian population who were complaining of having any allergic disease were taken and tested using the microarray. A total of 16,408 (71.1%) patients exhibited an IgE response to at least 1 of the 75 allergens used in the microarray. The most common allergen that caused an IgE response was the cypress pollen allergen Cup a 1, which 42% of patients reacted to. The next most common allergens to stimulate an IgE response were the house dust mite allergen Der f 2 (38.7% of patients), the recombinant pollen allergen Phl p1 (37.9% of patients), and the rye grass pollen allergen Lol p1 (36.9% of patients). Over one-third of the study population showed sensitivity to another common house dust mite allergen, Der p 2, with Der p1 and Der f 1 causing reactions in 24.6% and 23.9% of the cohort, respectively. Sensitivity to the major cat allergen Fel d1 was found in 20% of patients and 19.5% were sensitive to Ole e1. Par j 1 and Par j 2 caused reactions in 22.1% and 25.7% of patients, respectively. The prevalence of sensitivity to these allergens varied according to patient age and gender. "This is just the picture for Italy," Dr. Mari observed. "As allergy sensitisation is strongly linked to environmental exposure, surveys using these tools should be carried out worldwide for a detailed description and comparison of IgE reactivity." Funding for this study was provided by the Italian Ministry of Health and VBC-Genomics. [Presentation title: Cross-Sectional Survey On IgE Reactivity In 23,077 Subjects Using An Allergen Molecule-Based Microarray Detection System. Abstract 62] E-mail this page to a friend or colleague! To print, use this version