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| |  Single-Dose Rabeprazole Increases Intragastric pH Better Than Pantoprazole in Patients With Nocturnal Heartburn: Presented at WCOG By Danny Kucharsky MONTREAL, CANADA -- September 14, 2005 -- Rabeprazole 20 mg increases 24-hour intragastric pH levels significantly more than pantroprazole 40 mg in patients with nocturnal symptoms, according to results from a study presented here September 13th at the World Congress of Gastroenterology (WCOG). The open-label, randomised, 2-way crossover study conducted in the United Kingdom involved 31 patients with Helicobacter pylori-negative gastroesophageal reflux disease (GERD) and a history of nocturnal heartburn (more than 1 episode weekly). Previously, study findings suggested that nighttime GERD symptoms could have a significant effect on patient quality of life and impair next-day mental and physical functioning, reported investigator Steven Warrington, MD, Hammersmith Medicines Research, Central Middlesex Hospital, London, United Kingdom. For the study, patients were given a single oral morning dose of rabeprazole 20 mg or pantoprazole 40 mg with at least a 14-day washout period before being given the other agent. Using ambulatory pH monitoring, intragastric pH was measured continuously from approximately 24 hours before dosing until 24 hours after dosing. The primary efficacy variable was area under the intragastric pH-time curve during the 24-hour period on days 0 and 1. Secondary variables included intragastric area under the curve (AUC) during hours 0 to 5, 5 to 11, 11 to 14, and 14 to 24 after dosing on days 0 and 1. Results show that mean intragastric pH AUC was significantly higher after rabeprazole than after pantoprazole dosing for all time intervals, including the overnight (14-24 hour) period (P </= .024). On day 1, the mean percent time with pH > 3 and > 4 was significantly higher after rabeprazole than after pantoprazole during the 24 hours after dosing and for all time periods. The mean percent time for intragastric pH > 3 at 0 to 14 hours on day 1 was 63 for rabeprazole 20 mg and 51 for pantoprazole 40 mg. At hours 14 to 24 on day 1, the mean percent times were 38 and 25, respectively, and at 0 to 24 hours on day 1 the mean percent times were 52 and 40, respectively. The mean percent time for intragastric pH > 4 at 0-14 hours on day 1 was 52 for rabeprazole 20 mg and 38 for pantoprazole 40 mg. The mean percent times at 14 to 24 hours on day 1 were 27 and 17, respectively, and at 0to 24 hours on day 1, the mean percent times were 41 and 29, respectively. The results of this study indicate a potential therapeutic advantage for rabeprazole compared with pantoprazole in treating nocturnal GERD, Dr. Warrington concluded. The study was supported by Eisai Ltd, United Kingdom, Eisai Inc., New Jersey, United States, and Janssen Pharmaceuticals, New Jersey, United States.
[Presentation title: Effect of Single Doses of Rabeprazole 20 mg and Pantoprazole 40 mg on 24-Hour Intragastric Acidity in Gastroesophageal Reflux Disease Patients With Nocturnal Heartburn. Abstract R.0054]
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