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Efavirenz Well Tolerated in Morning: Presented at IAS-HIV By Charlene Laino RIO DE JANEIRO, BRAZIL -- July 25, 2005 -- Once-daily treatment with efavirenz can be administered safely in the morning to HIV-infected patients, researchers reported here on July 25th at the 3rd International AIDS Society Conference on HIV Pathogenesis and Treatment (IAS-HIV). While once-daily efavirenz is recommended in the evening, most patients prefer taking once-daily treatments in the morning (J STD AIDS 2003;14:34-36) and adherence is better when patients take their medications in the morning rather than in the evening (Antiviral Therapy 2004;9:85-89), said Oystein Maeland, MD, Professor, department of infectious diseases, Ullevaal University Hospital, Oslo, Norway. To determine whether patients can tolerate efavirenz in the morning, Dr. Maeland and colleagues conducted a study of patients who had been taking efavirenz for a minimum of 1 month and were asked to switch from evening to morning dosing. A total of 49 patients who had been on efavirenz for a mean of 16 months agreed to switch to morning dosing and comprised the final cohort. Concomitant medications were continued twice daily. One week and 4 weeks after switching to morning dosing, all the patients completed a questionnaire comparing adverse effects. After 4 weeks, patients were also asked if they would rather continue taking efavirenz in the morning or return to evening dosing. Of the total group, 49% of patients chose to continue taking efavirenz in the morning. Reasons for continuing to take efavirenz in the morning included sleeping better, being less drowsy during the day, and having fewer strange dreams. Several patients commented that "it is easier to remember to take pills in the morning." The other 51% participants chose to return to taking efavirenz in the evening. Reasons for the switch included impaired concentration, dizziness, and lightheadedness. Several patients who chose to return to evening dosing commented, "I have to take other medications in the evening so there is no advantage for me to take efavirenz in the morning," Dr. Maeland said. "This suggests morning dosing may be even more relevant when all antiretrovirals can be taken once daily." Prior time on efavirenz, gender, and work status did not affect time of efavirenz dosing, he said. [Presentation title: Can Efavirenz Be Taken in the Morning? Abstract WePe12.3C03] E-mail this page to a friend or colleague! To print, use this version