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Some Patients on Haemodialysis May Benefit From Improved Serum 25(OH)D Levels: Presented at NKF By Carole VanSickle Ellis ORLANDO, Fla -- April 20, 2010 -- Improving serum 25-hydroxyvitamin D (25[OH]D) may aid in lowering pulse pressure (PP) and systolic blood pressure (SBP) in patients on maintenance haemodialysis who are vitamin D deficient, researchers said here on April 15 at the National Kidney Foundation (NKF) 2010 Spring Clinical Meetings. Debra Blair, MD, University of Medicine and Dentistry of New Jersey, Newark, New Jersey, and colleagues examined the relationships between serum 25(OH)D levels and risk factors for cardiovascular disease (CVD) in patients on maintenance haemodialysis. They retrospectively collected data on 344 patients receiving maintenance dialysis at Fresenius Medical Care in Springfield, Massachusetts. The data collected spanned a 6-month period and included levels in serum 25(OH)D and use of ergocalciferol for patients deemed deficient. The team focused on diastolic blood pressure (DBP), SBP, PP, serum total cholesterol, and serum triglycerides. Researchers found significant relationships between risk factors for CVD and serum 25(OH)D at baseline for the group as a whole. However, for the 318 patients who were prescribed ergocalciferol, while their mean serum 25(OH)D measurements improved, their mean SBP, DBP, and PP trended downward at 6 months. However, pointed out Dr. Blair, these relationships did not reach statistical significance. Of the patients dosed, 21 improved in their serum 25(OH)D measures from <30 ng/mL at baseline to >70 ng/mL at follow-up, while their PP and SBP fell significantly. The 45 patients who were not on antihypertensive medications at baseline also experienced improvement in their mean PP, which decreased as serum 25(OH)D increased. While "more research is needed to determine optimal vitamin D levels and supplementation strategies, improving serum 25(OH)D may aid in lowering PP and SBP in maintenance haemodialysis patients who are vitamin D deficient," the researchers concluded. [Presentation title: Vitamin D [25(OH)D] and Its Relationship to Risk Factors for Cardiovascular Disease in Maintenance Hemodialysis Patients. Abstract 98] E-mail this page to a friend or colleague! To print, use this version