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Bioavailable Testosterone Is Protective Against Alzheimer’s Disease in Elderly Chinese Men: Presented at ADI By Jenny Powers THESSALONIKI, Greece -- March 15, 2010 -- Bioavailable testosterone (BT) is a strong factor in decreased risk for the development of Alzheimer’s disease (AD) in healthy elderly Chinese men, according to study results reported here at the 25th Conference of Alzheimer’s Disease International (ADI). Leung-Wing Chu, MBBS, FRCP, FHKAM (Med), Department of Medicine, University of Hong Kong, Hong Kong, Hong Kong Special Administrative Region of China, presented the results of a 1-year prospective cohort study on March 11. Because limited data correlated testosterone with AD, Dr. Chu and colleagues investigated the protective effects of serum total testosterone (TT) and BT levels on the risk of developing AD in healthy Chinese older men. The study enrolled 153 ambulatory community-living Chinese elderly men who had not been diagnosed with AD (National Institute of Neurological and Communicative Disorders and Stroke and the Alzheimer’s Disease and Related Disorders Association criteria) at baseline. Morning blood samples were collected from all subjects to determine TT and BT levels. The primary endpoint was the development of Alzheimer’s disease (AD) at 1-year follow-up. Eighty-three percent of the enrolled subjects were included in the follow-up. Of those, 6.5% (n = 10) developed AD. Multivariate logistic regression analyses for independent predictors of AD showed baseline serum BT levels, systolic blood pressure, and apolipoprotein E (ApoE) E4 genotype to be independent predictors (after adjustment for age, education, body weight, body mass index, fasting plasma glucose level, serum high-density lipoprotein cholesterol, and sex-hormone-binding globulin levels). Baseline serum BT level was an independent protective factor for AD, with an adjusted relative risk of 0.22 (95% confidence interval, 0.07-0.69). Baseline systolic blood pressure and ApoE E4 genotype were independent risk factors for the development of AD, with relative risks of 1.04 and 5.04, respectively. Dr. Chu concluded that bioavailable testosterone is a strong protective factor against the development of AD in healthy elderly Chinese men, whereas systolic blood pressure and ApoE E4 genotype are risk factors favouring the development of AD. [Presentation title: Bioavailable Testosterone Decreases the Risk of Alzheimer’s Disease in Non-Demented Chinese Older Men: A One Year Cohort Study. Abstract OC149] E-mail this page to a friend or colleague! To print, use this version