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Chromogranin A, Pancreatic Polypeptide Can Detect Gastropancreatic Endocrine Tumour Progression: Presented at ENETS By Karen Dente BERLIN -- March 14, 2010 -- Adding pancreatic polypeptide (PP) to the principal tumour marker chromogranin A (CgA) may increase the sensitivity in the diagnosis of gastroenteropancreatic neuroendocrine carcinoma (GEP-NET), according to findings presented here at the 7th Annual European Neuroendocrine Tumor Society (ENETS) Conference. “While CgA is considered the principal biochemical tumour marker for such tumours, its use to evaluate morphological tumour progression is not validated,” the authors wrote. Thomas Walter, MD, Hôpital Edouard Herriot and Hospices Civils de Lyon, Lyon, France, and colleagues investigated 115 patients with GEP-NET for their study with the goal of evaluating the sensitivity of CgA and PP in the presence of GEP-NET and to compare changes in morphology with altered CgA and PP serum levels. The dosage of CgA and PP were compared with clinical and morphological data. Elevated CgA and PP levels were found in 62 (54%) and 18 (16%) of cases, respectively. Both biochemical markers were significantly more elevated in tumours originating in the pancreas and in advanced stage. Of all patients, only 5 with duodenopancreatic NET had normal CgA and PP levels. Both markers had a higher sensitivity in tumours originating from the pancreas and in advanced stage. “Measurement of pancreatic polypeptide makes it possible to detect very few false-negative CgA in well-differentiated GEP-NET patients,” the authors wrote. The authors concluded that their study does not validate the use of CgA or PP as surrogate markers for detecting tumour evolution. [Presentation title: Interest of Combined Chromogranin A and Pancreatic Polypeptide for Diagnosis and Follow-Up of Gastroenteropancreatic Endocrine Carcinoma. Abstract B30] E-mail this page to a friend or colleague! To print, use this version