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Study Finds Direct Correlation Between Folate Deficiency, Cognitive Impairment: Presented at ADI By Jenny Powers THESSALONIKI, Greece -- March 13, 2010 -- An evaluation of the nutritional status of elderly patients shows that many with cognitive impairment also have folate deficiency, researchers said here on March 11 at the 25th Conference of Alzheimer’s Disease International (ADI). Folate levels may serve as an additional marker for Alzheimer’s disease risk in addition to increased homocysteine levels, the researchers said. The Latino population has a higher risk of developing Alzheimer’s disease, and it is currently not known whether this risk is due to genetic or environmental factors. Ivonne Z. Jimenez-Velazquez, MD, Internal Medicine Department Geriatrics Program, University of Puerto Rico School of Medicine, San Juan, Puerto Rico, and colleagues invited all residents aged 65 years and older from Puerto Rico to participate in this prospective community-based cohort study. A total of 2,000 elderly residents were interviewed and their cognitive function evaluated. Of the 2,000 individuals, a subgroup of 474 individuals who had been evaluated returned for a second visit that included a physical exam and blood test after fasting. Serum homocysteine, vitamin B12, and folate levels were compared with cognitive function. The data indicated a statistically significant correlation (P = .013) between folate deficiency and Diagnostic and Statistical Manual of Mental Disorders (Fourth Edition) dementia criteria. No correlation between vitamin B12 levels or elevated serum homocysteine and cognitive function was found. They authors concluded that comprehensive nutritional evaluation in elderly patients is essential. They recommend an assessment of folate levels in every patient aged over 65 years old, particularly when cognitive impairment or risk for Alzheimer’s disease is suspected. [Presentation title: Homocysteine, Vitamin B12, Folate and Cognitive Function. Abstract P037] E-mail this page to a friend or colleague! To print, use this version