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Gastric Bypass Surgery Increases Risk of Kidney Stones DALLAS -- March 10, 2010 -- Patients who undergo gastric bypass surgery experience changes in their urine composition that increase their risk of developing kidney stones, according to a study published in the March issue of The Journal of Urology. The study found that some of these urinary changes place weight-loss surgery patients at higher risk for developing kidney stones than obese patients who do not undergo the procedure. For the study, researchers collected urine samples from 38 study participants. There were 16 women and 3 men in each of 2 groups. One group had undergone Roux-en-Y gastric bypass (RYGB) surgery; the second group contained normal obese individuals. The researchers found that the excretion of a material called oxalate in urine was significantly greater in the participants who had the surgical procedure than those who did not (47% vs 10.5%, respectively). In addition, the amount of citrate in the urine was low in many gastric bypass patients in comparison with the obese nonsurgical group (32% vs 5%). “Almost half of the patients who had undergone gastric bypass and did not have a history of kidney stones showed high urine oxalate and low urine citrate -- factors that lead to kidney-stone formation,” said lead author Naim Maalouf, MD, Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, Texas. The cause for stone formation after bariatric surgery is not entirely clear, but the study reinforces the message that weight-loss surgery patients and their physicians should be alert to the heightened risk, said Dr. Maalouf. “These findings illustrate that the majority of patients are at risk for kidney-stone formation after RYGB,” Dr. Maalouf said. “This complication may not be well-recognised in part because it tends to occur months to years after the bypass surgery.” SOURCE: University of Texas Southwestern Medical Center E-mail this page to a friend or colleague! To print, use this version