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Pluronic Lecithin Organogel Safe Alternative for Elders Unable to Take Oral Psychotropic Agents: Presented at AAGP By Carole VanSickle Ellis SAVANNAH, Ga -- March 9, 2010 -- A big stumbling block to effective mood and behavioural treatments in elderly psychiatric patients could be removed by using pluronic lecithin organogel (PLO) creams to administer psychotropic agents to patients, researchers said here on March 7 at the 2010 Annual Meeting of the American Association for Geriatric Psychiatry (AAGP). Since many elderly patients are unwilling, unable, or unreliable when it comes to taking oral medications, topical ointments compounded of PLO substrate and the psychotropic medication may be the answer. Cornelius Thomas, MD, Department of Psychiatry and Neurobehavioral Sciences, University of Virginia in Charlottesville, Virginia, and colleagues analysed the medical charts of 24 patients in the University of Virginia’s nursing home outreach service who were treated with psychotropic medications compounded with the PLO gel. Patients’ age was 86.8 +- 5.9 years. Medications administered most commonly as a PLO cream included quetiapine and venlafaxine. They all exhibited common psychiatric behaviours including agitation, depression, decreased appetite, insomnia, and noncompliance with oral medication. Their symptoms were common, and included aggressive behaviour, anxiety, and depression. Both behaviours and symptoms were evaluated as part of the review process, since it was important to determine not only whether the creams were effective, but also if they effectively improved the medicating situation for both patients and caregivers. All patients had mild to marked improvement in their clinical conditions using PLO as a means to administer psychiatric medication. “This retrospective offers evidence that PLO is a safe, effective vehicle for topical administration of psychotropic medication in geriatric patients,” Dr. Cornelius concluded. [Presentation title: Administration of Psychotropic Medication Using Topical PLO Cream. Abstract EI11] E-mail this page to a friend or colleague! To print, use this version