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Surgery Plus Hyperthermic Intraperitoneal Chemotherapy Show Promise for Ovarian Cancer: Presented at SSO By Jill Stein ST. LOUIS, Mo -- March 9, 2010 -- Long-term survival is likely in women who undergo complete cytoreduction followed by hyperthermic intraperitoneal chemotherapy (HIPEC) for peritoneal surface dissemination (PSD) from ovarian cancer, according to data presented here on March 6 at the 2010 Society of Surgical Oncology Annual Cancer Symposium (SSO). Nikki Parson, Wake Forest University School of Medicine, Winston-Salem, North Carolina, and colleagues presented results from 51 patients who underwent aggressive tumour debulking followed by HIPEC with either mitomycin C, carboplatin, cisplatin or paclitaxel. All patients had PSD from ovarian neoplasms. The 5-year survival rate for International Federation of Gynecology and Obstetrics (FIGO) stage III and IV ovarian cancer is less than 25%. A recent Cochrane meta-analysis suggests that normothermic chemotherapy following debulking can result in improved overall and progression-free survival, she added. However, there are limited data on the use of HIPEC for ovarian cancer. In the present study, the primary outcome measure was long-term survival. Patients were followed for 31.1 months, on average. The median length of hospitalisation was 8.5 days. The median survival for the entire cohort was 28.5 months. The 1-year survival rate was 73% +- 6%, the 3-year survival rate was 48% +- 7%, and the 5-year survival rate was 28% +- 7%. When patients were stratified by their resection status, the median survival was 47 months in women undergoing R0/R1 resections versus 19 months in R2a patients, 6 months in R2b patients, and 11 months in R2c patients. Resection status and estimated blood loss were found to be independently associated with survival. The results demonstrate that cytoreductive surgery and HIPEC is an attractive treatment modality for patients with PSD from ovarian cancer, Parson said. She added that more studies are needed to assess the clinical utility of the approach this cohort of patients, the investigators said. [Presentation title: Outcomes After Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for Peritoneal Surface Dissemination From Ovarian Neoplasm. Abstract P280] E-mail this page to a friend or colleague! To print, use this version