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AAPM: Study Shows Strong Link Between Depression and Painful Complaints By Paula Moyer PALM SPRINGS, CA -- February 28, 2005 -- Pain is more likely to be a part of the lives of people who live with depression than it is for those who are free from depression, according to research presented here on February 25th at the 21st annual meeting of the American Academy of Pain Medicine. The same study's findings show that among individuals who have chronic pain, those with depression will report more severe pain and worse functioning, and use more medications than do non-depressed people. Previous studies showed that people with depression are more likely to experience painful physical symptoms, and that individuals with depression who also experience pain are known to have worse outcomes from their depression than do those without pain, said principal investigator Rebecca Robinson, MS, senior researcher at Eli Lilly and Company in Indianapolis, Indiana, United States. In addition, she said, pain is known to add to the economic and disease burden of people who live with depression. To track the confluence of pain and depression and clarify the relationship between pain and depression, Ms. Robinson and colleagues analyzed the data from a 23-year longitudinal study. The data set involved 424 patients who were being treated for major depressive disorder and 424 matched community controls, all recruited in 1980 and responded to a mailed survey at enrollment and 2003. Among the cohort of people treated for depression, 248 were available at follow-up. Of the 233 on whom data were complete, 145 were experiencing pain symptoms and 88 were pain-free. Among the controls, 273 were available for follow-up. Among the 263 for whom data were available, 127 had pain symptoms and 136 had no pain symptoms. In addition, among participants who reported expiring pain, 15.9% had major depressive disorder, compared to 6.3% of those without pain (P <.013). Participants who were being treated for depression at the start of the study also had more symptoms of pain over baseline at the 23-year follow-up on the Patient Health Questionnaire compared to those who did not have depression at baseline (2.99 vs. 2.14, P <.001). The group with baseline depression was also more likely to have pain-related disability at follow-up as determined with the Graded Chronic Pain Scale (30.16 vs. 18.12, P <.001). Participants who reported having both pain symptoms and depression at 23-year follow-up used significantly more medications daily (3.59 vs. 1.81, P <.001) and more days of activity lost due to pain than did those who did not have depression (5.38 days/month 3.39 days/month, P <.015). Among those who were not experiencing pain at 23-year follow-up, the only difference between patients with depression and those without depression was the number of medications ever used, averaging 2.38 for depressed patients and 0.933 for non-depressed patients (P <.001). Ms. Robinson said her study's findings show the importance of screening for depression when treating patients with chronic pain. [Presentation title: The Relationship and Outcomes of Depression and Painful Complaints: A 23-Year Follow-Up. Abstract #136] E-mail this page to a friend or colleague! To print, use this version