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Childhood Measles May Protect Against Hodgkin's Lymphoma: Presented at ESMO By Charlene Laino BUDAPEST, HUNGARY -- June 9, 2005 -- Childhood measles and chickenpox may offer some protection against Hodgkin's lymphoma, findings from a case-control study suggest. Maurizio Montella, MD, Epidemiologist, Istituto Tumori Fondazione Pascale, Naples, Italy, presented the findings during a poster session here on June 4th at the European Society of Medical Oncology Scientific & Educational Conference (ESMO). Noting that several viral and bacterial infections have been implicated in the development of lymphohaematopoetic neoplasms, Dr. Montella said the current study was designed to explore possible associations between childhood infections and development of non-Hodgkin's and Hodgkin's lymphomas. The study enrolled 225 patients with histologically confirmed non-Hodgkin's lymphoma, 62 patients with Hodgkin's lymphoma, and 504 controls with no signs of cancer. All were aged 18 years or older. A multiple logistic regression model that controlled for age, gender, education, and place of birth showed that people who had childhood measles were 66% less likely to have Hodgkin's lymphoma, compared with those who did not have measles (95% confidence interval [CI] 0.17-0.68). Childhood chickenpox appeared to reduce the risk of Hodgkin's lymphoma cases by 47% (95% CI 0.23-0.93), the researchers reported. "There was a trend toward lower rates of parotitis, rubella, pertussis, and scarlet fever in Hodgkin's lymphoma patients," Dr. Montella said. Measles was also associated with a significant 40% reduction in the risk of non-Hodgkin's lymphoma (95% CI 0.5-0.9), the study showed. When the researchers looked at major histological subtypes, negative associations tended to be stronger for follicular B-cell non-Hodgkin's lymphoma than for diffuse large B-cell or other non-Hodgkin's lymphoma subtypes, he said. Specifically, people who had measles in childhood were 71% less likely to have follicular B-cell non-Hodgkin's lymphoma than those who never had measles. Also, people who reported a history of three childhood infections or more were 40% less likely to have non-Hodgkin's lymphoma (95% CI 0.4-1.0) and 80% less likely to have Hodgkin's lymphoma (95% CI 0.1-0.6), compared with those that reported no infection. "In conclusion, the present results give some support to the hypothesis that infections with common childhood pathogens may protect from Hodgkin's lymphoma or, at least, be correlated to some other early exposure that may lower the risk of Hodgkin's lymphoma in adult life," Dr. Montello commented in an email. [Presentation title: Childhood Infections and the Risk of Lymphomas: a Case-Control Study. Abstract 119-P] E-mail this page to a friend or colleague! To print, use this version