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AAN: No Differences Seen in Interferon Beta Products in QUASIMS Study By Ed Susman MIAMI, FL -- April 22, 2005 -- Researchers investigating different interferon beta products and modes of delivery in patients with relapsing multiple sclerosis reported that they found no significant difference in efficacy or safety between products. Lead author Volker Limmroth, MD, associate professor and vice chairman, department of neurology, University of Essen, Essen, Germany, said the Quality Assessment in Multiple Sclerosis Therapy Study (QUASIMS) confirms initial findings that interferon beta products and dosing regimens have comparable outcomes and safety. Results of the initial analysis, presented in 2003, involved more than 4700 patients in 510 sites in Germany, Austria, and Switzerland. The new subanalysis, which involved an expanded group of 7,156 patients living in Australia, Brazil, BeNeLux, Italy, Slovakia, Greece, Portugal, Spain, and Argentina, was presented here April 14th at the American Academy of Neurology 57th Annual Meeting. The study compared the following interferon beta therapies: --Interferon beta-1a (Avonex®) 30 mcg IM once weekly --Interferon beta-1b (Betaferon®/Betaseron®) 8 MIU SC every 2 days --Interferon beta-1a (Rebif®) 22 mcg SC 3 times weekly --Interferon beta-1a (Rebif®) 44 mcg SC 3 times weekly Dr. Limmroth said the only differences in treatment were observed in patients who were switched from 1 treatment modality to another. "Observed treatment effects were generally less favourable when interferon beta products were used as follow-up therapy than when used as initial therapy," he said. "The results suggest that patients do not gain further benefit when switching from 1 interferon beta product to another." [Presentation title: Results From the Global QUASIMS Study: Comparison of the Efficacy and Tolerability of Interferon-Beta Products for the Treatment of Relapsing Multiple Sclerosis in Australia, Brazil, Benelux, Italy, and Slovakia. Abstract P05.123] E-mail this page to a friend or colleague! To print, use this version