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Quetiapine XR Monotherapy Effective for Different Depression Severity Levels: Presented at EPA By Jenny Powers MUNICH, Germany -- March 5, 2010 -- Quetiapine extended-release (XR) monotherapy demonstrated significant efficacy in a study that evaluated the response in patients with major depressive disorder (MDD) at several different levels of severity. Patients responded to quetiapine XR at all levels, including the most severe, researchers said here on March 1 at the European Psychiatric Association (EPA) 18th European Congress of Psychiatry. Stuart Montgomery, MD, Imperial College School of Medicine, London, United Kingdom, presented an analysis of pooled data from 4 studies (D1448C00001, D1448C00002, D1448C00003, and D1448C00004) evaluating the efficacy of quetiapine XR as a monotherapy for MDD in a total of 1,752 patients. The primary endpoint was the change post randomisation in Montgomery-Asberg Depression Rating Scale (MADRS) total score. Change from randomisation in MADRS total score and MADRS response was defined as >= 50% reduction in MADRS total score at endpoint (week 6 or week 8) in 6 severity stages which were defined by a MADRS total score at randomisation (>=24, >=26, >=28, >=30, >=32 or >=34). The mean MADRS total score at endpoint in “all patients” (P < .001 vs placebo) and in all 6 levels of severity (P < .001 vs placebo) was reduced with quetiapine XR treatment. The MADRS response rates were significantly higher in the quetiapine XR group versus placebo in the all-patients group (P < .001 vs placebo) and in all 6 severity levels (P = .001 vs placebo). It was concluded from the change in MADRS scores that that quetiapine XR was significantly effective as a monotherapy in the treatment of patients with MDD at all levels of severity. Funding for this study was provided by AstraZeneca. [Presentation title: Evaluation of the Effects of Quetiapine XR Monotherapy According to MDD Severity: Pooled Data From 4 Placebo-Controlled Trials. Abstract PW01-24] E-mail this page to a friend or colleague! To print, use this version