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Children, Adolescents With ADHD Demonstrate Improved Functioning After Transition to OROS Methylphenidate Treatment: Presented at EPA By Jenny Powers MUNICH, Germany -- March 4, 2010 -- Transition to treatment with the long-acting osmotic controlled-release (OROS) formulation of methylphenidate (MPH) was associated with statistically significant improvement in daily functioning and quality of life in nonadult patients with attention deficit hyperactivity disorder (ADHD), according to a study presented here at the European Psychiatric Association (EPA) 18th European Congress of Psychiatry. Barbara Schaeuble, MD, EMEA Medical Affairs Division, Janssen-Cilag, Neuss, Germany, presented the findings on February 28. She focused on this pooled analysis of 2 similarly designed 12-week, open-label, flexible-dose studies that included 822 patients (aged 6-18 years) and defined the functionality and quality of life in these patients transitioning from previous treatments to OROS MPH (median dose at baseline and endpoint was 36 mg/day). ADHD symptoms improved as indicated by the statistically significant decrease in Conners’ Rating Scale score by 10.83 +- 11.17 points (P < .0001). Children’s Global Assessment Scale ratings improved by 12.01+- 14.03 points (P < .00001). No serious treatment-emergent adverse events were observed. The investigators concluded that transition to OROS MPH improved daily functioning and quality of life in children and adolescents with ADHD. Symptom improvement was associated with better social functioning and improved quality of life. The burden of disease was decreased in patients and their caregivers, and the long-acting, controlled formulation of MPH was generally well tolerated. Funding for this study was provided by Janssen-Cilag GmbH. [Presentation title: Transitioning Onto OROS MPH Is Associated With Improved Functioning and Quality of Life in Children and Adolescents With ADHD. Abstract P03-347] E-mail this page to a friend or colleague! To print, use this version