Women Fare Worse Than Men After Stroke if tPA Treatment is Not Received
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Women Fare Worse Than Men After Stroke if tPA Treatment is Not Received

ST. PAUL, Minn -- March 2, 2010 -- New research shows women who don’t receive a clot-busting drug after a stroke fare worse than men who are not treated. The study is published in the March 2 print issue of Neurology.

“Women need to be treated for stroke as soon as possible,” said study author Michael D. Hill, MD, University of Calgary in Alberta, Calgary, Alberta. “We found that women who weren’t treated had a worse quality of life after stroke than men. However, the good news is that women who were treated responded just as well as men to the treatment.”

For the study, researchers examined information from a stroke database on 2,113 people who had experienced a stroke. Of those, 232 were treated with the clot-busting drug known as tissue plasminogen activator (tPA) and 44% were women.

Men and women were separately placed in groups based on whether they received tPA within 3 hours after their stroke. After 6 months, the people were interviewed by phone about their ability to function and quality of life.

The study found that women who did not receive the clot-busting drug were 12% less likely than men to have a good outcome 6 months later, or 58% of the women compared with 70% of men.

However, women who were treated with these medications fared about the same as men who took the clot-buster drug.

“There could be many reasons why women who weren’t treated with the clot-busting drug fared worse than men, including biological reasons,” said Dr. Hill. “One social reason may be that more than 30% of women were widowed compared with 7% of men at the time of stroke, and therefore did not have a spouse who could act as a caregiver. Also, post-stroke depression is more common in women than in men, which slows down recovery.”

SOURCE: American Academy of Neurology

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