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| |  Intravenous Acetaminophen Reduces Pain, Opioid Consumption After Hip or Knee Surgery: Presented at AAPM By Jennifer Reising SAN ANTONIO, Tex -- February 9, 2010 -- Intravenous (IV) acetaminophen provides significant analgesic efficacy and a reduction in opioid consumption, compared with placebo, according to a study presented here at the 26th annual meeting of the American Academy of Pain Medicine (AAPM). “[Intravenous acetaminophen] is currently under review by the FDA for the treatment of acute pain and fever in adults and children,” said lead investigator Mike A. Royal, MD, Cadence Pharmaceuticals, San Diego, California, during a poster presentation on February 4. Researchers conducted a meta-analysis of 3 randomised, double-blind, placebo-controlled trials (RC 210-3-002, RC 136-01-03, and RC 136-02-03) in which 231 patients received IV acetaminophen 1,000 mg (n = 114) or placebo (n = 117) after total hip or knee arthroplasty. Intravenous acetaminophen produced an opioid-sparing effect -- defined as a >=30% reduction in opioid consumption or avoidance of the need for opioid rescue -- for the first dosing interval ranging from 46% to 63% among the 3 studies. In studies 136-01-03 and 136-02-03, 43% and 50% of patients, respectively, did not require any rescue opioid during the treatment period. The onset of analgesia was rapid in all 3 studies and with a significant difference occurring by the end of the 15-minute infusion for many of the endpoints. Adverse events were comparable to placebo in all 3 studies Funding for this study was provided by Cadence Pharmaceuticals, Inc. [Presentation title: IV Acetaminophen Produces Clinically Meaningful Pain Response and Opioid Sparing Effect After Major Orthopedic Surgery: Pooled Data From Three Randomized, Placebo-Controlled Trials. Abstract 200]
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