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Carisoprodol Relieves Acute Lower Back Spasm, Pain: Presented at AAPM By Jennifer Reising SAN ANTONIO, Tex -- February 8, 2010 -- Patients with acute musculoskeletal low back pain achieved a clinically meaningful improvement in their symptoms within 3 days when treated with carisoprodol, researchers reported here at the 26th annual meeting of the American Academy of Pain Medicine (AAPM). “Based on a review of published literature, carisoprodol 250 mg is the only skeletal muscle relaxant proven to significantly improve functionality in patients with acute low back pain,” commented William J. Wheeler, PhD, Meda Pharmaceuticals, Somerset, New Jersey, on February 3. Dr. Wheeler and colleagues analysed the results from 2 randomised, controlled, multicentre trials that took place from August 2005 to June 2006. The studies evaluated 1,080 patients (aged 18-65 y) with moderate to severe investigator-rated muscle spasm and patient-reported backache. Patients were randomised to carisoprodol 250 mg (n = 533) or placebo (n = 547) 4 times daily for 7 days. Functional status was assessed at baseline and at day 3 using the Roland-Morris Disability Questionnaire (RMDQ). The mean baseline RMDQ scores were similar in both groups: 10.9 in the carisoprodol-treated group and 10.7 in the placebo group. The primary endpoint was a >=30% improvement in RMDQ by day 3 of treatment. On day 3, the carisoprodol group had achieved a clinically meaningful improvement in RMDQ: 31%, with a mean change of 3.4 from baseline, compared to a 17.2% improvement, with a mean change of 1.8, in the placebo group. Patients in either treatment group reported adverse events of drowsiness, dizziness, and headache; however, no serious adverse events were reported in these studies. Meda Pharmaceuticals supported the studies from which these data were generated. [Presentation title: Functional Status of Patients With Acute Low Back Pain Following Treatment With Carisoprodol 250-mg Tablets Assessed by the Roland-Morris Disability Questionnaire (RMDQ). Abstract 156] E-mail this page to a friend or colleague! To print, use this version