Oropharyngeal Dysphagia Common, Increases Mortality After Lung Transplantation: Presented at STS
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Oropharyngeal Dysphagia Common, Increases Mortality After Lung Transplantation: Presented at STS

By Charlene Laino

FORT LAUDERDALE, Fla -- January 28, 2010 -- Oropharyngeal dysphagia is surprisingly common and increases mortality after lung transplantation, researchers reported here on January 26 at the Society of Thoracic Surgeons (STS) 46th Annual Meeting.

“Oropharyngeal dysphagia is often overlooked when relying solely on clinical assessment of deglutition,” said Broudus Z. Atkins, MD, Department of Surgery, Durham Veterans Administration Medical Center, Durham, North Carolina. “Provocative testing is required for accurate detection.”

The researchers reviewed the records of 263 consecutive patients who underwent lung transplantation at their institution from January 2001 to July 2005.

All patients underwent a provocative swallowing evaluation in the early postoperative period, and 149 patients underwent additional fibre optic or videofluoroscopic swallowing evaluation.

The mean age of the patients, 51% of whom were male, was 49 years. A total of 20.1% had previous thoracic surgery, and 49.7% had preoperative gastro-oesophageal reflux disease (GERD).

Among the 149 patients who went additional testing, the swallowing evaluation was positive in 105 (70.5%). Among those with positive swallowing evaluations, 64% suffered aspiration and 36% had laryngeal penetration.

Positive results on the swallowing evaluation did not increase the combined endpoint of death and bronchiolitis obliterans, a known risk factor for reduced graft function and longevity (P = .8), Dr. Atkins reported.

However, patients with normal or negative postoperative swallowing evaluation results were 86% less likely to die in the postoperative period compared with those with positive results (P = .005).

“Mechanisms for oropharyngeal dysphagia are likely multifactorial and could be treatment- or patient-related,” he said, citing a history of GERD, pulmonary disease, and tobacco use.

[Presentation title: Oropharyngeal Dysphagia Increases Mortality After Orthotopic Lung Transplantation. Abstract 62]



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