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Pneumonectomy Raises Lung Resection Mortality Risk: Presented at STS By Charlene Laino FORT LAUDERDALE, Fla -- January 27, 2010 -- The strongest predictors of mortality after resection for lung cancer are pneumonectomy and poor performance status, according to a retrospective review presented here at the Society of Thoracic Surgeons (STS) 46th Annual Meeting. “We found some very powerful predictors of mortality that will help improve patient care in the future,” said Benjamin D. Kozower, MD, Surgery and Public Health Sciences, University of Virginia, Charlottesville, Virginia, on January 25. The researchers reviewed data in the STS General Thoracic Database on 18,800 patients who had undergone surgery for lung cancer between 2002 and 2008. “Two-thirds of patients had a lobectomy for their lung resection,” said Dr. Kozower. “Wedge resection was the second most common procedure, and pneumonectomies were rare, at 6%.” Perioperative mortality occurred in 413 patients (2.2%). Major morbidity occurred in 1,491 patients (7.9%). The median length of stay following lung cancer resection was 5 days. The greatest predictor of mortality was pneumonectomy, which increased the risk of dying 3.9-fold, compared with lobectomy (P < .001). Poor physical status before surgery increased the mortality risk 3.6-fold (P = .004) and poor performance status increased the risk 3.1-fold (P < .001). Induction chemoradiation therapy, but not induction chemotherapy alone, doubled the risk of death (P = .01). Steroids were also an important predictor of mortality, raising risk 1.9 fold (P = .002). [Presentation title: Predictors of Mortality and Major Morbidity After Resection for Lung Cancer -- A Society of Thoracic Surgeons General Thoracic Surgery Database Risk Model. Abstract 2] E-mail this page to a friend or colleague! To print, use this version