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AACR: Acetaminophen May Increase NHL Risk in Women By Charlene Laino ORLANDO, FL -- March 31, 2004 -- Acetaminophen appears to increase the risk of non-Hodgkin lymphoma (NHL) in women, but not men, and aspirin is associated with a small, but insignificant, decrease in NHL risk in both genders, a case-control study shows. Julie A. Baker, MS, RN, an MD, PhD candidate at Roswell Park Cancer Institute, Buffalo, New York, United States, presented the findings here on March 30th at the American Association for Cancer Research 95th Annual Meeting. Noting that results of previous trials have been inconsistent, Ms. Baker said her team sought to correlate NHL risk and use of aspirin and acetaminophen in 628 patients with primary, incident NHL and 2,512 hospital controls with neither benign nor malignant disease who were matched for age and sex. Unconditional logistic regression analysis showed that people who used aspirin regularly were 13% less likely to have NHL than non-users, but the result was not significant (95% CI 0.73–1.04). Similar odds ratios were observed for people who used aspirin 1 to 6 times per week and those who took it 7 or more times per week, Ms. Baker said. Men who took acetaminophen on a regular basis were 24% less likely to develop NHL than men who did not take it, but again the result was not significant (95% CI 0.49-1.19). Among women, those who took acetaminophen regularly were 70% more likely to develop NHL than non-users (95% CI 1.17-2.47), the study showed. "Due to an inflammatory mechanism associated with NHL, we hypothesised that we would see a decreased risk with aspirin and no effect with acetaminophen," Ms. Baker said. "So we went to the literature in search of a plausible explanation and found that several studies have shown that acetaminophen use is associated with decreased DNA repair, allowing it to act as a co-mutagen." While the results need to be confirmed in a prospective trial, Ms. Baker said that it might be prudent to tell women with risk factors for NHL to substitute acetaminophen with non-steroidal anti-inflammatory drugs, unless contraindicated. [Study title: Regular Use of Aspirin or Acetaminophen and Risk of Non-Hodgkin's Lymphoma. Abstract 3721] E-mail this page to a friend or colleague! To print, use this version