If this is not your name, click here.
| | If this is not your name, click here. | | |
| | Contact Us | Order Now | Journals | Bookstore | Register a colleague | | |
| |  Childhood Metabolic Measurements May Predict Diabetes Development Years Later CHICAGO -- January 4, 2010 -- A child’s blood pressure, body mass index, blood glucose level, and other laboratory tests and simple office measures may predict the risk of developing type 2 diabetes 9 and 26 years later, according to a study published in the January issue of Archives of Pediatrics & Adolescent Medicine. John A. Morrison, PhD, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, and colleagues analysed data from 2 studies. The National Growth and Health Study followed 1,067 black and white girls enrolled at ages 9 and 10 for nine years, and the Princeton Follow-up Study tracked 822 black and white schoolchildren for 22 to 30 years beginning in 1973 to 1976. In the Princeton Follow-up Study, individuals were more likely to have diabetes at age 39 years if they had high systolic blood pressure, a high body mass index, glucose levels of at least 100 mg per deciliter, low high-density lipoprotein (HDL) levels and high triglyceride levels in childhood. “When body mass index, systolic blood pressure and diastolic blood pressure were all lower than the 75th percentile and there was no parental diabetes, the likelihood of children developing type 2 diabetes 22 to 30 years later was only 1%,” the authors wrote. In the National Growth and Health Study, childhood high systolic blood pressure, insulin concentration, and having a parent with diabetes increased the risk of having diabetes at age 19. “If childhood body mass index, systolic blood pressure and diastolic blood pressure were all lower than the 75th percentile, the likelihood of type 2 diabetes at age 19 years was 0.2%; 0.2% if the parents were also free of diabetes; 0.3% if childhood insulin was also less than the 75th percentile,” the authors wrote. “Our data have practical clinical value in assessment of pre-teenaged and teenaged children, since children with systolic blood pressure, triglyceride, body mass index, and insulin in the top fifth percentile, a glucose concentration of at least 100 mg per deciliter and a parent with diabetes could be targeted for primary prevention of type 2 diabetes mellitus through diet, exercise, and possibly insulin-sensitising drug intervention, with special focus on overweight children with positive family history of diabetes mellitus,” they concluded.
SOURCE: Archives of Pediatrics & Adolescent Medicine
|
