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Progesterone May Be a Treatment Option for Traumatic Brain Injuries RESTON, Va -- December 22, 2009 -- Researchers recommend that progesterone be considered a viable treatment option for traumatic brain injuries, according to a clinical perspective published in the January issue of the American Journal of Roentgenology. “Traumatic brain injury is an important clinical problem in the United States and around the world,” said lead author Donald G. Stein, PhD, Emory University, Atlanta, Georgia. “Traumatic brain injury has received more attention recently because of its high incidence among combat casualties in Iraq and Afghanistan,” he said. “Current Department of Defense statistics indicated that as many as 30% of wounded soldiers seen at Walter Reed Army Hospital have suffered a TBI, a finding that has stimulated government interest in developing a safe and effective treatment for this complex disorder.” “Growing evidence indicates that post-injury administration of progesterone in a variety of brain damage models can have beneficial effects, leading to substantial and sustained improvements in brain functionality,” said Dr. Stein. “Progesterone given to both males and females can cross the blood-brain barrier and reduce oedema levels after; in different models of cerebral ischaemia, significantly reduce the area of necrotic cell death and improve behavioural outcomes; and protect neurons distal to the injury that would normally die,” said Stein. Progesterone was recently tested in 2 phase 2 clinical trials for traumatic brain injury and will begin a phase 3 trial soon. “Given its relatively high safety profile, its ease of administration, its low cost and ready availability, progesterone should be considered a viable treatment option -- especially because, in brain injury, so little else is currently available,” said Dr. Stein. SOURCE: American Roentgen Ray Society E-mail this page to a friend or colleague! To print, use this version