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Ultrasound Identifies Cancer in Symptomatic Women Aged 30 to 39 Years: Presented at RSNA By Ed Susman CHICAGO -- December 3, 2009 -- Targeted ultrasound imaging of suspected breast lesions appears to be warranted among women aged 30 to 39 years, researchers said here at the Radiological Society of North America (RSNA) 95th Annual Meeting. “Although the risk of these breast lesions in women being malignant is small, about 2% of them do turn out to be cancer,” said Constance Lehman, MD, PhD, University of Washington, Seattle, Washington. “We found that ultrasound has a high sensitivity -- 100% in this study -- in evaluating the area of clinical concerns,” she said at a press briefing on December 2. “The added value of mammography in this setting is less apparent.” Dr. Lehman noted, “For women aged 30 to 39 with focal breast signs or symptoms, mammography is typically performed to complement targeted ultrasound of the area of concern and to screen the remaining breast for cancer. “The purpose of this study was to determine the added value of mammography in women 30 to 39 years of age undergoing breast US [ultrasound] for evaluation of focal breast signs or symptoms. There is little data regarding the added benefit of mammography in those women aged 30 to 39 years.” Researchers scrutinised 1,327 cases of focal symptoms that occurred among 1,032 women from 2002 to 2006. In 875 of the cases, women reported a suspicious lump in the breast. Another 115 women complained of pain in a specific area of the breast. One percent of women said they had both pain and a lump, and another 1% described other symptoms. Of those cases, 1,301 were determined to be benign lesions and 26 cases (2% of the total) were malignancies. All of the cancers were identified by the use of targeted ultrasound, Dr. Lehman noted. “None of the cancers were identified by mammography alone,” she said. Based on the findings, the authors determined that the sensitivity of ultrasound at the area of clinical concern was 100% and of mammography was 64%. She also said that the specificity of ultrasound was 89% and the specificity of mammography was 94%. Mammography resulted in detection of 1 additional malignancy in an asymptomatic area of the breast in a 32-year-old woman subsequently found to have a BRCA2 gene mutation. [Presentation title: Contribution of Mammography to Ultrasound Evaluation of Women 30 to 39 Years of Age With Focal Breast Signs or Symptoms. Abstract SSK02-09] E-mail this page to a friend or colleague! To print, use this version