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Glucose Intolerance During Pregnancy Associated With Postpartum Cardiovascular Risk CHEVY CHASE, Md -- December 2, 2009 --Women who have gestational glucose intolerance exhibit multiple cardiovascular risk factors as early as 3 months after birth, according to a new study that will be published in the February 2010 issue of The Endocrine Society’s Journal of Clinical Endocrinology & Metabolism (JCEM). Lead study author Ravi Retnakaran, MD, Mount Sinai Hospital and the University of Toronto, Toronto, Ontario, and colleagues sought to evaluate the relationship between gestational glucose intolerance and postpartum risk of metabolic syndrome. They followed 487 women who underwent oral glucose tolerance testing during pregnancy. Each subject was classified as either having normal glucose tolerance, gestational glucose intolerance, or gestational diabetes. At 3 months post partum, they evaluated the subjects’ cardiometabolic characteristics -- blood pressure, weight, waist measurement, and lipid levels. Findings support that even mild glucose intolerance during pregnancy predicts an increased likelihood of the metabolic syndrome at 3 months post partum. The presence of cardiovascular risk factors as early as 3 months post partum indicates that these risk factors may be longstanding and contribute to the long-term risk of cardiovascular disease in this patient population. “The study findings raise the important possibility that women with gestational glucose intolerance and subsequent postpartum metabolic syndrome represent a patient population at particularly high risk for the future development of metabolic and vascular disease,” said Dr. Retnakaran. “Further research with long-term follow-up is needed to address this possibility.” “Our data also suggests that glucose tolerance screening in pregnancy, as is currently practiced, may provide previously unrecognised insight into a woman’s postpartum cardiovascular risk-factor profile,” said Dr. Retnakaran. “Furthermore, glucose tolerance screening may identify subgroups of young women for whom cardiovascular risk-factor monitoring may be warranted.” SOURCE: The Endocrine Society E-mail this page to a friend or colleague! To print, use this version